CliniMACS Prodigy® Clinical Use – Miltenyi Biotec
CliniMACS Prodigy® represents the new generation of automated cell separation machines with an immunomagnetic process. It has advanced and integrated solutions regarding the processing and separation of cells from cell culture, also contributing to the formulation of the final product.
CliniMACS Prodigy offers a flexible platform for applications that enable immunomagnetic separation of different cell types with automated protocols.
The cell processing unit for fully automated cell separation, fractionation and culture is an integral part of the CliniMACS Prodigy and these processes are performed in a closed system so that there is no possibility of graft’s contamination. It is equipped with a determination camera for excellent cell fractionation. The immunomagnetic cell separation unit comprises a second integral part of the CliniMACS Prodigy.
With the CliniMACS Prodigy® immunomagnetic separator it is possible to isolate particularly important cell populations for the recipient such as:
- a) CD 34 HSC aimed at the complete recovery of the patient without the risk of GVHD
- b) TCR α/β in order for the patient to receive the necessary cell populations for a complete cure, as well as protective cell populations, without the risk of GVHD
- c) CD45RA in order for the patient to be transplanted with these therapeutic cells.
- d) T-Virus Specific Cells in order for the recipient, through the purification of the transplant, to receive all the necessary cell products for the treatment of viruses (CMV, Adenovirus, EBV, etc.)
It is a flexible operating platform so that with the CliniMACS Prodigy® system it is possible to program therapeutic protocols, such as the production of therapeutic T cells with Chimeric Antigen Receptors (CAR T Cells).
